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KMID : 0379520010170020091
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한국독성학회지
2001 Volume.17 No. 2 p.91 ~ p.96
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Dermal and Ocular Irritation Studies of Some Phthalates in Rabbits
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Lee Jong-Kwon
Kim Joo-Hwan
Lee Eun-Hee
Kim Yong-Kyu
Hong Jin-Tae
Park Ki-Sook
Ahn Kwang-Soo
Jung Soo-Yeon
Lee Sun-Hee
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Abstract
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Phthalates are widely used as plasticizers to impart softness and flexibility to normally rigid polyvinylchloride products. However, there are not much studies jar dermal and ocular irritation toxicity of phthalates. So we investigated the skin or eye irritation effect of some phthalates which was not reported. The primary skin irritation of diethyl phthalate (DEP), diisodecyl phthalate (DIDP), diisononyl phthalate (DINP), dipropyl phthalate (DPP) and dipropyl phthalate (DPrP) was studied. The ocular irritation of dibutyl phthalate(DBP), DIDP, DINP, DPP and DPrP was also studied. DEP, DIDP, DINP, DPP, and DPrP were found to be non-irritating to the skin of the test animals. DBP, DIDP, DINP and DPP were found to be non-irritating to the eye of the rabbits. DPrP caused the slight irritations to the eye in 1 or 2 days after treatment but irritation of the animals was soon recovered.
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KEYWORD
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Phthalate, Skin irritation, Eye irritation, Rabbit
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